Department: Pharmacological Sciences

Physical work location: (must be proper street address):1468 Madison Ave (Anbg Building) 19th Fl

Name PI or Supervisor: (include phone and email): Lahouaria Hadri

Web link to Lab: https://labs.icahn.mssm.edu/hadrilab/lahouaria-hadri/

Web link to Department: https://icahn.mssm.edu/about/departments/pharmacological-sciences

Administrative Contact: (phone and email): Yoori Kim, 212-6598651, yoori.kim@mssm.edu

Responsibilities

This project aims to investigate the genomic, molecular, and epigenetic mechanisms driving the progression of pulmonary fibrosis and lung diseases. Using integrative transcriptomic, epigenomic, proteomic, and bioinformatic analyses, the goal is to identify key signaling pathways and potential therapeutic targets.

The laboratory is embedded within an interdisciplinary research environment and is equipped with state-of-the-art facilities for molecular and cellular biology, chromatin biology, and drug and gene therapy development. The research will involve close collaboration with scientists from complementary disciplines and will utilize in vitro, ex vivo, and in vivo mouse models to study vascular cell and fibroblast cross-talk and dysfunction, as well as the epigenetic mechanisms underlying inflammatory and cardiopulmonary vascular diseases in small and large animal studies.

Approaches include advanced techniques in transcriptomics, chromatin and epigenomic profiling, and proteomics to comprehensively characterize disease mechanisms and inform therapeutic innovation.

The successful candidate will lead original research aimed at elucidating the molecular mechanisms of gene transcription and cell signaling in both physiological and disease contexts. This includes the application of molecular and cellular biology techniques, chromatin biology, genomic sequencing technologies, and the use of animal models.

In addition to conducting research, the candidate will provide technical training and mentorship to junior scientists, ensuring the development of strong experimental and analytical skills within the team. They will also coordinate collaborative studies with partnering laboratories to advance project objectives and foster interdisciplinary innovation.

Educational and other Requirements for the position: PhD

Qualifications

The ideal candidate will hold an MD/PhD or Ph.D. in molecular or cell biology, with demonstrated research experience in chromatin biology, and the use of animal models to study human disease. Prior experience in managing research projects is highly desirable.

A strong publication record in relevant scientific areas will be valued. The candidate should be a fast learner, highly motivated, and collaborative, with a rigorous approach to experimental design, data analysis, and organizational tasks. Effective written and oral communication skills are essential for success in a dynamic, interdisciplinary research environment.

Goals/Outcomes of the Research Project:

This research project aims to advance fundamental knowledge in transcriptional regulation and disease mechanisms, with the ultimate goal of contributing to the development of novel therapeutic strategies for the treatment and prevention of disease. Successful outcomes are expected to lead to new grant funding opportunities and high-impact publications in leading scientific journals, thereby enhancing the visibility and translational potential of the research.

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About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

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