Location: Icahn School of Medicine at Mount Sinai, New York City

The Mzoughi Lab focuses on:

1. Dissecting the epigenetic mechanisms underlying phenotypic heterogeneity and plasticity by integrating lineage tracing with cutting-edge multiomics technologies.

2. Investigating the relationship between tumor behavior and their developmental origins through a combination of computational modeling and experimental approaches.

We are seeking a highly motivated and skilled Post-Doctoral Researcher or Scientist to join our team. This position offers an exciting opportunity to contribute to cutting-edge research in functional epigenetics and cancer evolution. As a key member of our team, you will play a crucial role in designing and executing experiments to characterize cell state dynamics and the underlying mechanisms during cancer evolution.

The successful candidate will work closely with wet and dry lab team members and the Principal Investigator (Dr. Mzoughi) to develop innovative strategies to reverse aberrant cell states in cancer. Staying abreast of the latest advancements in the field of epigenetic plasticity and high impact publications are also expected.

Our group collaborates closely with the Techno-Omics Research unit, embedded within the Center for Oncogenomics and Innovative Therapeutics, to develop new single-cell omics tools.

Responsibilities

Key Responsibilities:

• Culture normal and cancer organoid models .

• Conduct genetic barcoding and lineage tracing experiments.

• Perform drug screens.

• Maintain and report accurate records of data.

• You will have the opportunity to be trained in bulk and single-cell genomics techniques, such as ATAC-seq, RNA-seq, and CUT&Tag.

Qualifications

Requirements:

• Ph.D. in a relevant field (e.g., cancer biology, molecular biology, (epi)genetics, or related disciplines).

• At least one first-author publication in a reputable journal.

• Proficiency in basic molecular biology techniques, including DNA/RNA extraction, PCR, qPCR, cloning, and western blotting.

• Preferred experience in ATAC-seq, ChIP-seq, RNA-seq, and/or working with organoids, mice, and genetic barcoding.

• Excellent organizational skills and attention to detail.

• Ability to work independently as well as collaboratively in a team-oriented environment.

• Effective communication and interpersonal skills.

The Mzoughi lab is dedicated to transformative basic and translational research aimed at improving cancer treatment and patient outcomes. By joining our young team, you will have the unique opportunity to work alongside dedicated researchers and clinicians who share a passion for making a meaningful impact in the field of oncology.

To apply, please submit a cover letter, CV, and contact information for three references to slim.mzoughi@mssm.edu. Please include "Post-Doctoral Researcher Application @Mzoughi Lab" in the subject line.

Mount Sinai is an equal opportunity employer, and we encourage applications from individuals of all backgrounds. We value diversity and inclusion in our research community.

Note: Only shortlisted candidates will be contacted for an interview.

Compensation Statement

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $74,692.00 - $80,000.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.

SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 824 - Oncological Sciences - ISM, Icahn School of Medicine

Strength through Unity and Inclusion

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

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About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

Equal Opportunity Employer

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.