The Organization

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible. Through proprietary and versatile approaches, Entrada is advancing a robust development portfolio of genetic medicines for the potential treatment of neuromuscular and inherited retinal diseases, among others. Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne muscular dystrophy (DMD) who are exon 44, 45, 50 and 51 skipping amenable. Entrada has partnered with Vertex Pharmaceuticals to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1 (DM1).

2026 represents a catalyst-rich period for Entrada. We expect multiple clinical data readouts as we advance several DMD programs across the U.K., EU, and U.S. By year-end 2026, we anticipate four clinical-stage programs in our DMD franchise (ENTR-601-44, ENTR-601-45, ENTR-601-50, and ENTR-601-51). These programs are complemented by the ongoing clinical progress of our DM1 collaboration with Vertex (VX-670).

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Addition to Our Team

You enjoy balancing strategic thinking with hands-on execution and take pride in delivering exceptional experiences for employees at every stage of their journey. You look forward to learning the business, partnering with leaders across the organization, and continuously growing your expertise across all facets of Human Resources. You want to join an organization where you can help build scalable people programs that support employees, strengthen culture, and drive business success. You believe that great employee experiences are built through thoughtful partnerships, continuous improvement, and a people-first mindset.

The Opportunity

We're looking for an HR professional who thrives on creating exceptional employee experiences while partnering across Talent Acquisition, HR Business Partnership, and Learning & Development. This role is ideal for someone who enjoys building programs, improving processes, and partnering with leaders to help employees succeed throughout their journey at Entrada.

Working closely with the Head of Talent Acquisition & Employee Experience and the Senior Director, HR Business Partner, you'll own key employee experience programs, support enterprise-wide talent initiatives, and contribute to many of the company's highest-impact HR priorities.

Responsibilities

Employee Experience & Onboarding

• Run and continuously enhance the end-to-end new hire experience, ensuring every employee has a seamless transition into Entrada.
• Lead new hire orientation and coordinate the Kickstart Entrada onboarding program in partnership with HR Business Partners.
• Support onboarding effectiveness through feedback and metrics, implementing improvements that strengthen employee engagement and productivity.
• Help leaders strengthen team engagement via employee engagement survey administration, focus groups, and action planning activities .
• Partner across HR to help develop initiatives that enhance the overall employee experience and reinforce Entrada's culture.

HR Business Partnership & Talent Programs

• Partner with the Senior Director, HR Business Partner to support enterprise talent initiatives, including performance management, talent reviews, employee development, promotions, and organizational effectiveness.
• Support managers and employees by providing guidance on HR policies, processes, and employee relations matters, escalating complex situations as appropriate.
• Assist with workplace investigations and employee relations activities, ensuring fair, consistent, and timely resolution.
• Support annual HR cycles by coordinating communications, tracking progress, analyzing data, and identifying opportunities for continuous improvement.
• Contribute to cross-functional HR projects that improve employee experience, operational efficiency, and organizational effectiveness.

Learning & Development

• Coordinate company-wide learning and development programs, including leadership development, manager training, and employee learning initiatives.
• Manage program logistics, communications, vendor coordination, and participant experience.
• Track program effectiveness and recommend enhancements based on employee feedback and business needs.

Talent Operations & Programs

• Lead the recruitment, coordination, onboarding, and enrichment of Entrada’s Co-Op Program.
• Maintain the company organizational chart and ensure organizational information remains current.
• Partner with HR Operations and Talent Acquisition to support post-offer activities, onboarding workflows, background checks, and HRIS data accuracy.
• Review and maintain HR documentation, including job descriptions, offer letters, and other employment-related materials.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

• Humanity - We genuinely care about patients and about one another.
• Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
• Creativity - We are creative problem solvers.
• Collaboration - We are more than the sum of our parts.
• Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

• Bachelor's degree with 4+ years of progressive Human Resources or Talent Acquisition experience, preferably within the biotechnology, pharmaceutical, or technology industry.
• Experience managing multiple priorities and projects in a fast-paced, evolving environment.
• Experience supporting employee experience, onboarding, learning & development, or HR business partnership initiatives preferred.
• Strong project management skills with exceptional attention to detail and follow-through.
• Excellent written and verbal communication skills.
• Ability to build trusted relationships with employees and leaders across all levels of the organization.
• A continuous improvement mindset with a passion for creating outstanding employee experiences.
• Strong analytical skills and comfort using data to inform recommendations and measure success.
• This is an On-Site working model, with in office attendance during core working hours 4-5 days a week at the Entrada Therapeutics Headquarters in Boston, MA

What We Offer: Meaningful Work, Fair Rewards, and Real Support

At Entrada Therapeutics, we understand that compensation and total rewards are a major consideration when exploring a new opportunity. We believe in transparency and equity and are committed to sharing salary ranges for every position, along with insight into our compensation philosophy, in accordance with certain state requirements in the United States and fostering a fair and open environment at the onset.

But we also know it is more than just pay. When you join Entrada, you’ll be part of a mission-driven team with access to comprehensive health, dental and vision coverage; life and disability insurance; with a 401(k) match. We pride ourselves on offering competitive benefits that empower our employees and reflect the value of their contributions – offering paid, gender-inclusive parental leave, holistic support for your health and well-being, education reimbursement, discretionary time off and commuting benefits aligned to your working model. If you find yourself working from our office in Boston’s Seaport District, this puts you steps away from some of the best the city has to offer.

At Entrada, our approach to compensation is grounded in transparency, equity, and performance, recognizing the unique contributions each person brings. We believe meaningful work deserves meaningful reward, and view compensation as one way to show appreciation for the collaboration, curiosity, and commitment that drive our mission forward.

The salary for this opportunity ranges from $98,000-$126,000. The final base compensation offered will depend on several considerations which include but may not be limited to a candidate’s skills, competencies, experience and other job-related factors permitted by law. The final salary offered may fall outside of this range. #LI-GG1 #LI-Onsite

Equal Opportunity Employer

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

Privacy Statement

Entrada Therapeutics, Inc. (the “Entrada,” “we,” “us,” or “our”) respects your privacy and we want you to be familiar with how we collect, use, share, or otherwise process, your Personal Information. Please reference our privacy statement here to understand how and when your data is being used.