Job Description

Role Summary

The Senior Director, Human Resources Business Partner (HRBP) provides strategic HR partnership to leaders across Global Commercial Strategy, U.S. Pricing & Access / Government Affairs, Global Pricing, and Health Economics & Outcomes Research (HEOR).

Reporting to the Head of HR for Commercialization, this role focuses on talent strategy, organizational design, and supporting commercial transformation efforts.

This role partners closely with the VP of Commercial Transformation to align people and organizational priorities with the broader Commercial Transformation agenda, and in support of the resources within the transformation office.

Key Responsibilities

HR Business Partnership

• Serve as a strategic HR advisor to senior leaders across multiple Commercialization functions
• Provide guidance on organization design, talent management, and workforce planning
• Support leaders in aligning people strategies to business priorities

Commercial Transformation Support

• Partner with Commercial Transformation leadership to support execution of transformation initiatives
• Translate business priorities into organizational and talent implications
• Support implementation of new operating models and ways of working

Talent Strategy

• Support identification and assessment of critical roles across Commercialization
• Partner with Talent and business leaders on succession planning and development strategies
• Contribute to capability-building and commercial excellence initiatives

Organizational Effectiveness & Change

• Support organizational design and change initiatives across supported functions
• Provide coaching and guidance to leaders during periods of change
• Use data and insights to inform talent and organization decisions

HR Delivery Model

• Partner with a shared People Advisor who supports employee relations, performance management processes, and day‑to‑day HR needs
• Ensure alignment between strategic priorities and HR program execution

Qualifications

• 10–12+ years of HR experience, including HR Business Partner roles in complex, matrixed organizations
• Experience supporting commercial, pricing, access, strategy, or value functions preferred
• Experience in organizational design, talent management, and change initiatives
• Strong business acumen and ability to influence senior stakeholders

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

$227,200 - $340,800

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.  From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1.    Hybrid: work remotely up to two days per week; or select
2.    On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com