At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description

Gilead Sciences' Protein Therapeutics Department has an exciting opportunity for a highly motivated Scientist to join the Protein Science group. In this role, the successful candidate will support multidisciplinary research teams through the generation, purification, bioconjugation, and analytical characterization of biologic molecules. The ideal candidate will possess hands-on expertise and a strong scientific foundation in antibody purification, bioconjugation, and protein analytics. Working collaboratively with project teams, this individual will help advance therapeutic discovery programs by generating and characterizing candidate molecules and surrogate research tools. They will contribute to the evaluation and selection of lead candidates across a broad range of modalities, including bispecific antibodies, immunocytokines, antibody-drug conjugates (ADCs), and other novel and complex biologics. Through scientific problem-solving, technical innovation, and data-driven decision making, the candidate will help accelerate the progression of large-molecule therapeutics from discovery to development.

Responsibilities:

• Design and execute protein purification, bioconjugation, and analytical characterization workflows to support therapeutic protein discovery and development programs.

• Develop, optimize, and troubleshoot purification and characterization methods for complex biologics.

• Analyze and interpret experimental data, draw scientifically sound conclusions, and recommend next steps to advance project objectives.

• Identify, evaluate, and implement new technologies and workflows to improve efficiency, throughput, and technical capabilities within the Protein Science group.

• Collaborate closely with therapeutic area biologists and cross-functional project teams to generate proteins and address project-specific scientific questions.

• Serve as a technical resource within multidisciplinary teams, providing expertise in protein purification, bioconjugation, and protein analytics.

• Present data and scientific findings to project teams and contribute to technical reports, invention disclosures, publications, presentations, and other scientific documentation.

• Provide technical training and mentorship to colleagues and support the development of departmental best practices.

Skills

• Strong scientific foundation in protein sciences

• Hands-on experience operating and programming ÄKTA Avant/Pure and/or Bio Rad NGC chromatography systems.

• Extensive experience in purification of biologic molecules using affinity chromatography (Protein A/G/L, CaptureSelect, Ni-NTA, etc.), ion exchange chromatography, size exclusion chromatography, hydrophobic interaction chromatography, and mixed-mode chromatography.

• Experience performing, analyzing, and interpreting quality and characterization assays for antibody-drug conjugates (ADCs).

• Proficiency in bioconjugation methods for protein and antibody-based therapeutics.

• Expertise in protein analytical techniques including HPLC/UHPLC, SDS-PAGE, CE SDS, endotoxin testing (e.g., Endosafe), and SEC-MALS.

• Working knowledge of construct design and molecular engineering for therapeutic proteins and surrogate tool molecules.

• Strong analytical, problem-solving, organizational, and communication skills, with the ability to interpret complex datasets and effectively communicate scientific findings.

Basic Qualifications:

Bachelor's Degree and 6  Years’ Experience

OR

Masters' Degree and 4 Years’ Experience

Preferred Qualifications:

• Experience with automated liquid handling and high-throughput protein purification platforms (e.g., Tecan).

• Experience with LC-MS characterization of biologics, including ADCs.

• Experience supporting the discovery and characterization of complex biologic modalities, such as bispecific antibodies, immunocytokines, and ADCs.

The salary range for this position is: $146,540.00 - $189,640.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

For jobs in the United States:

Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance.

For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster.

NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT
YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT

Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, (c) consistent with the  legal duty to furnish information; or (d) otherwise protected by law.

Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:

Please apply via the Internal Career Opportunities portal in Workday.